产品名称
HMGCS2 Rabbit Polyclonal Antibody
蛋白名称
Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3158
Human Swissprot No.
P54868
Human Swissprot Link
https://www.uniprot.org/uniprot/P54868
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15360
Mouse Swissprot No.
P54869
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P54869/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P22791/entry
特异性
This antibody detects endogenous levels of HMGCS2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161). Not detected in brain (PubMed:21952825). ; [Isoform 3]: Highest expression detected in heart and skeletal muscle.
功能
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
