产品名称
GW182 Rabbit Polyclonal Antibody
基因名称
TNRC6A CAGH26 KIAA1460 TNRC6
蛋白名称
Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27327
Human Swissprot No.
Q8NDV7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NDV7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233833
Mouse Swissprot No.
Q3UHK8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UHK8/entry
特异性
This antibody detects endogenous levels of GW182 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, P-body . Mammalian P-bodies are also known as GW bodies (GWBs). .
功能
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
