产品名称
SMURF1 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57154
Human Swissprot No.
Q9HCE7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HCE7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75788
Mouse Swissprot No.
Q9CUN6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CUN6/entry
特异性
This antibody detects endogenous levels of SMURF1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in melanocytes (PubMed:23999003).
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
功能
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Plays a role in dendrite formation by melanocytes .
