产品名称
Hepcidin-25 Rabbit Polyclonal Antibody
基因名称
HAMP HEPC LEAP1 UNQ487/PRO1003
蛋白名称
Hepcidin (Liver-expressed antimicrobial peptide 1) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Cleaved into: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57817
Human Swissprot No.
P81172
Human Swissprot Link
https://www.uniprot.org/uniprot/P81172
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84506
Mouse Swissprot No.
Q9EQ21
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQ21/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84604
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q99MH3/entry
特异性
This antibody detects endogenous levels of Hepcidin-25 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood (PubMed:11034317). Expressed by hepatocytes (PubMed:15124018).
功能
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma . Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes . ; Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa .
