产品名称
SLC40A1 Rabbit Polyclonal Antibody
基因名称
SLC40A1 FPN1 IREG1 SLC11A3 MSTP079
蛋白名称
Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30061
Human Swissprot No.
Q9NP59
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NP59
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53945
Mouse Swissprot No.
Q9JHI9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHI9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170840
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q923U9/entry
特异性
This antibody detects endogenous levels of SLC40A1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen.
细胞定位
Cell membrane ; Multi-pass membrane protein . Localized to the basolateral membrane of polarized epithelial cells.
功能
Major iron transporter that plays a key role in balancing cellular and systemic iron levels . Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma .
