产品名称
TRP1 Rabbit Polyclonal Antibody
基因名称
TYRP1 CAS2 TYRP TYRRP
蛋白名称
5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7306
Human Swissprot No.
P17643
Human Swissprot Link
https://www.uniprot.org/uniprot/P17643
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22178
Mouse Swissprot No.
P07147
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P07147/entry
特异性
This antibody detects endogenous levels of TRP1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Melanosome membrane ; Single-pass type I membrane protein . Melanosome . Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. .
功能
Plays a role in melanin biosynthesis . Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) . May regulate or influence the type of melanin synthesized . Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
