产品名称
SNX27 Rabbit Polyclonal Antibody
基因名称
SNX27 KIAA0488 My014
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81609
Human Swissprot No.
Q96L92
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96L92
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76742
Mouse Swissprot No.
Q3UHD6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UHD6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=260323
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K4V4/entry
特异性
This antibody detects endogenous levels of SNX27 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed in cells of hematopoietic origin (at protein level).
细胞定位
Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
功能
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
