产品名称
KDM6B/JMJD3 Rabbit Polyclonal Antibody
基因名称
KDM6B JMJD3 KIAA0346
蛋白名称
Lysine-specific demethylase 6B (EC 1.14.11.-) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23135
Human Swissprot No.
O15054
Human Swissprot Link
https://www.uniprot.org/uniprot/O15054
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=216850
Mouse Swissprot No.
Q5NCY0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5NCY0/entry
特异性
This antibody detects endogenous levels of KDM6B/JMJD3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code . Demethylates trimethylated and dimethylated H3 'Lys-27' . Plays a central role in regulation of posterior development, by regulating HOX gene expression . Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).
