产品名称
Noxa Rabbit Polyclonal Antibody
蛋白名称
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5366
Human Swissprot No.
Q13794
Human Swissprot Link
https://www.uniprot.org/uniprot/Q13794
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58801
Mouse Swissprot No.
Q9JM54
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JM54/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=492821
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U777/entry
特异性
This antibody detects endogenous levels of Noxa at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in adult T-cell leukemia cell line.
功能
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
