产品名称
TTLL12 Rabbit Polyclonal Antibody
蛋白名称
Tubulin--tyrosine ligase-like protein 12
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23170
Human Swissprot No.
Q14166
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14166
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=223723
Mouse Swissprot No.
Q3UDE2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UDE2/entry
特异性
This antibody detects endogenous levels of TTLL12 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions.
细胞定位
Cytoplasm . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Nucleus . Predominantly localizes in the cytoplasm (PubMed:28011935). Partially colocalizes with vimentin in prostate cancer cells (PubMed:20162578). .
功能
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues . Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) . Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability . During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE .
