产品名称
RGS3 Rabbit Polyclonal Antibody
蛋白名称
Regulator of G-protein signaling 3 (RGP3) (RGS3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5998
Human Swissprot No.
P49796
Human Swissprot Link
https://www.uniprot.org/uniprot/P49796
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50780
Mouse Swissprot No.
Q9DC04
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DC04/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54293
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P49797/entry
特异性
This antibody detects endogenous levels of RGS3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Nucleus . Cell membrane ; Peripheral membrane protein . Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).
功能
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
