产品名称
Neudesin/NENF Rabbit Polyclonal Antibody
蛋白名称
Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Secreted protein of unknown function) (SPUF protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29937
Human Swissprot No.
Q9UMX5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UMX5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66208
Mouse Swissprot No.
Q9CQ45
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQ45/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=289380
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6IUR5/entry
特异性
This antibody detects endogenous levels of Neudesin/NENF at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.
细胞定位
Secreted, extracellular space . Mitochondrion . Endoplasmic reticulum . Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. .
功能
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival . Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity).
