产品名称
MFSD2 Rabbit Polyclonal Antibody
基因名称
MFSD2A MFSD2 HMFN0656 PP9177 UNQ300/PRO341
蛋白名称
Major facilitator superfamily domain-containing protein 2A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84879
Human Swissprot No.
Q8NA29
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NA29
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76574
Mouse Swissprot No.
Q9DA75
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DA75/entry
特异性
This antibody detects endogenous levels of MFSD2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
In placenta, associated with trophoblast cells.
细胞定位
Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cytoplasmic punctae that may represent vesicles shuttling between the endoplasmic reticulum and the plasma membrane (PubMed:21677192). .
功能
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function . Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain . Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation . In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion .
