产品名称
INADL Rabbit Polyclonal Antibody
蛋白名称
InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10207
Human Swissprot No.
Q8NI35
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NI35
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12695
Mouse Swissprot No.
Q63ZW7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q63ZW7/entry
特异性
This antibody detects endogenous levels of INADL at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in renal tubules (at protein level) (PubMed:19755384). Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.
细胞定位
Cell junction, tight junction . Apical cell membrane ; Peripheral membrane protein . Cytoplasm, perinuclear region . Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (PubMed:11964389). Localized in the paranodal region of myelinating Schwann cells (By similarity). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). .
功能
Scaffolding protein that facilitates the localization of proteins to the cell membrane . Required for the correct formation of tight junctions and epithelial apico-basal polarity . Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries .
