产品名称
FLII Rabbit Polyclonal Antibody
蛋白名称
Protein flightless-1 homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2314
Human Swissprot No.
Q13045
Human Swissprot Link
https://www.uniprot.org/uniprot/Q13045
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14248
Mouse Swissprot No.
Q9JJ28
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ28/entry
特异性
This antibody detects endogenous levels of FLII at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Strongest expression in skeletal muscle with high expression also in the heart and lung.
细胞定位
Nucleus . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell junction, focal adhesion . Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). .
功能
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
