产品名称
STIL Rabbit Polyclonal Antibody
蛋白名称
SCL-interrupting locus protein (TAL-1-interrupting locus protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6491
Human Swissprot No.
Q15468
Human Swissprot Link
https://www.uniprot.org/uniprot/Q15468
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20460
Mouse Swissprot No.
Q60988
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60988/entry
特异性
This antibody detects endogenous levels of STIL at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer.
细胞定位
Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole .
功能
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 . Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly .
