产品名称
PHEX Rabbit Polyclonal Antibody
蛋白名称
Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5251
Human Swissprot No.
P78562
Human Swissprot Link
https://www.uniprot.org/uniprot/P78562
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18675
Mouse Swissprot No.
P70669
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70669/entry
特异性
This antibody detects endogenous levels of PHEX at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Specifically expressed in ovary (PubMed:9070861). Expressed at low levels in kidney (PubMed:9070861).
细胞定位
Cell membrane ; Single-pass type II membrane protein .
功能
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity . Cleaves ASARM peptides between Ser and Glu or Asp residues . Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide . Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides . Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation .
