产品名称
TIAR Rabbit Polyclonal Antibody
蛋白名称
Nucleolysin TIAR (TIA-1-related protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7073
Human Swissprot No.
Q01085
Human Swissprot Link
https://www.uniprot.org/uniprot/Q01085
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21843
Mouse Swissprot No.
P70318
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70318/entry
特异性
This antibody detects endogenous levels of TIAR at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain, heart, kidney, lung and skeletal muscle.
细胞定位
Nucleus . Cytoplasm . Cytolytic granule . Cytoplasm, Stress granule . Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). .
功能
RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation . Shows a preference for uridine-rich RNAs . Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 . Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) . Possesses nucleolytic activity against cytotoxic lymphocyte target cells . May be involved in apoptosis .
