产品名称
RNF126 Rabbit Polyclonal Antibody
蛋白名称
RING finger protein 126
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55658
Human Swissprot No.
Q9BV68
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BV68
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70294
Mouse Swissprot No.
Q91YL2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YL2/entry
特异性
This antibody detects endogenous levels of RNF126 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in liver and testis.
细胞定位
Cytoplasm . Nucleus .
功能
E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins . Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates (By similarity). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome . May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor . May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination . By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation . May monoubiquitinate AICDA .
