产品名称
PRMT2 Rabbit Polyclonal Antibody
蛋白名称
Protein arginine N-methyltransferase 2 (EC 2.1.1.-) (Histone-arginine N-methyltransferase PRMT2) (EC 2.1.1.125)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3275
Human Swissprot No.
P55345
Human Swissprot Link
https://www.uniprot.org/uniprot/P55345
Mouse Swissprot No.
Q9R144
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R144/entry
特异性
This antibody detects endogenous levels of PRMT2 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord.
细胞定位
[Isoform 1]: Cytoplasm. Nucleus. Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus.; [Isoform PRMT2Alpha]: Nucleus. Excluded from nucleolus.; [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus.; [Isoform PRMT2Gamma]: Nucleus. Excluded from nucleolus.; [Isoform PRMT2L2]: Cytoplasm . Nucleus . Predominantly cytoplasmic.
功能
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
