产品名称
PDE12 Rabbit Polyclonal Antibody
蛋白名称
2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=201626
Human Swissprot No.
Q6L8Q7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6L8Q7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=211948
Mouse Swissprot No.
Q3TIU4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TIU4/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AXQ5/entry
特异性
This antibody detects endogenous levels of PDE12 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion matrix .
功能
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP . Also cleaves 3',5'-phosphodiester bond of oligoadenylates . Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells .
