产品名称
XPNPEP3 Rabbit Polyclonal Antibody
蛋白名称
Probable Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=63929
Human Swissprot No.
Q9NQH7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NQH7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=321003
Mouse Swissprot No.
B7ZMP1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/B7ZMP1/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=685823
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B5DEQ3/entry
特异性
This antibody detects endogenous levels of XPNPEP3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
细胞定位
[Isoform 1]: Mitochondrion . Cytoplasm . Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation. .; [Isoform 2]: Cytoplasm .
功能
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala . Also shows low activity towards peptides with Ala or Ser at the P1 position . ; [Isoform 1]: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling.
