产品名称
PHACTR1 Rabbit Polyclonal Antibody
基因名称
PHACTR1 KIAA1733 RPEL1
蛋白名称
Phosphatase and actin regulator 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=221692
Human Swissprot No.
Q9C0D0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9C0D0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=218194
Mouse Swissprot No.
Q2M3X8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q2M3X8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=306844
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P62024/entry
特异性
This antibody detects endogenous levels of PHACTR1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in umbilical vein endothelial cells.
细胞定位
Cytoplasm . Cell junction, synapse . Nucleus . Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). .
功能
Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity . Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
