产品名称
ANO6 Rabbit Polyclonal Antibody
蛋白名称
Anoctamin-6 (Transmembrane protein 16F)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=196527
Human Swissprot No.
Q4KMQ2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q4KMQ2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=105722
Mouse Swissprot No.
Q6P9J9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P9J9/entry
特异性
This antibody detects endogenous levels of ANO6 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
细胞定位
Cell membrane ; Multi-pass membrane protein . Shows an intracellular localization according to PubMed:22075693.
功能
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. ; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
