产品名称
SYTL2 Rabbit Polyclonal Antibody
基因名称
SYTL2 KIAA1597 SGA72M SLP2 SLP2A
蛋白名称
Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54843
Human Swissprot No.
Q9HCH5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HCH5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83671
Mouse Swissprot No.
Q99N50
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99N50/entry
特异性
This antibody detects endogenous levels of SYTL2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.
细胞定位
[Isoform 1]: Cytoplasm . Cell membrane . Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. .; [Isoform 4]: Cell membrane . In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. .
功能
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
