产品名称
PDS5A Rabbit Polyclonal Antibody
基因名称
PDS5A KIAA0648 PDS5 PIG54
蛋白名称
Sister chromatid cohesion protein PDS5 homolog A (Cell proliferation-inducing gene 54 protein) (Sister chromatid cohesion protein 112) (SCC-112)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23244
Human Swissprot No.
Q29RF7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q29RF7
Mouse Swissprot No.
Q6A026
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6A026/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=305343
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/A4L9P7/entry
特异性
This antibody detects endogenous levels of PDS5A at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
细胞定位
Nucleus . Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase. .
功能
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
