产品名称
EXT2 Rabbit Polyclonal Antibody
蛋白名称
Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2132
Human Swissprot No.
Q93063
Human Swissprot Link
https://www.uniprot.org/uniprot/Q93063
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14043
Mouse Swissprot No.
P70428
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70428/entry
特异性
This antibody detects endogenous levels of EXT2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Golgi apparatus, cis-Golgi network membrane ; Single-pass type II membrane protein . The EXT1/EXT2 complex is localized in the Golgi apparatus.
功能
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan .
