产品名称
SYT7 Rabbit Polyclonal Antibody
蛋白名称
Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O43581
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43581/entry
Mouse Swissprot No.
Q9R0N7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0N7
免疫原
Synthesized peptide derived from part region of human protein
特异性
SYT7 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011],
组织表达
Expressed in a variety of adult and fetal tissues.
细胞定位
Cell membrane ; Single-pass membrane protein . Cell junction, synapse, presynaptic cell membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass membrane protein . Peroxisome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63. .
功能
cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,domain:The second C2 domain/C2B is responsible for SYNCRIP binding.,function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subunit:Interacts with SYNCRIP isoform 3 C-terminus.,tissue specificity:Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidneys and lung.,tissue specificity:Expressed in a variety of adult and fetal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
