产品名称
OTUD5 Rabbit Polyclonal Antibody
蛋白名称
OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55593
Human Swissprot No.
Q96G74
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96G74
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54644
Mouse Swissprot No.
Q3U2S4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U2S4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363452
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q2YDU3/entry
特异性
This antibody detects endogenous levels of OTUD5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.
功能
Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 .
