产品名称
FAM175A Rabbit Polyclonal Antibody
基因名称
FAM175A ABRA1 CCDC98 UNQ496/PRO1013
蛋白名称
BRCA1-A complex subunit Abraxas (Coiled-coil domain-containing protein 98) (Protein FAM175A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84142
Human Swissprot No.
Q6UWZ7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6UWZ7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70681
Mouse Swissprot No.
Q8BPZ8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BPZ8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=289468
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5I0F1/entry
特异性
This antibody detects endogenous levels of FAM175A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Localizes at sites of DNA damage at double-strand breaks (DSBs). .
功能
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
