产品名称
SYT5 Rabbit Polyclonal Antibody
蛋白名称
Synaptotagmin-5 (Synaptotagmin V) (SytV)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O00445
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00445/entry
Mouse Swissprot No.
Q9R0N5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R0N5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P47861
免疫原
Synthesized peptide derived from part region of human protein
特异性
SYT5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011],
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein . Recycling endosome membrane ; Single-pass membrane protein . In mast cells, localizes to the endocytic recycling compartment. .
功能
cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subcellular location:In mast cells, localizes to the endocytic recycling compartment.,subunit:Homodimer. Can also form heterodimers. Interacts with both alpha- and beta-tubulin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
