产品名称
PDCL3 Rabbit Polyclonal Antibody
蛋白名称
Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79031
Human Swissprot No.
Q9H2J4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H2J4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68833
Mouse Swissprot No.
Q8BVF2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BVF2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=316348
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4KLJ8/entry
特异性
This antibody detects endogenous levels of PDCL3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in endothelial cells (at protein level) (PubMed:26059764). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon (PubMed:15371430).
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Endoplasmic reticulum .
功能
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation . Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding . Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis .
