产品名称
FKBP6 Rabbit Polyclonal Antibody
蛋白名称
Peptidyl-prolyl cis-trans isomerase FKBP6 (PPIase FKBP6) (EC 5.2.1.8) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) (Rotamase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8468
Human Swissprot No.
O75344
Human Swissprot Link
https://www.uniprot.org/uniprot/O75344
Mouse Swissprot No.
Q91XW8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91XW8/entry
特异性
This antibody detects endogenous levels of FKBP6 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
细胞定位
Cytoplasm, cytosol . Nucleus . Chromosome . Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity). .
功能
Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).
