产品名称
PREPL Rabbit Polyclonal Antibody
蛋白名称
Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9581
Human Swissprot No.
Q4J6C6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q4J6C6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=213760
Mouse Swissprot No.
Q8C167
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C167/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=298771
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5HZA6/entry
特异性
This antibody detects endogenous levels of PREPL at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813). Widely expressed (PubMed:15913950, PubMed:16385448). Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448). Expressed at the endplates in the neuromuscular junction (PubMed:24610330).
细胞定位
Cytoplasm, cytosol . Golgi apparatus, trans-Golgi network . Cytoplasm, cytoskeleton . Golgi apparatus . Nucleus . Co-localizes with AP-1 in the trans-Golgi network (By similarity). Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). .
功能
Serine peptidase whose precise substrate specificity remains unclear . Does not cleave peptides after a arginine or lysine residue . Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex . May play a role in the regulation of synaptic vesicle exocytosis .
