产品名称
OLFM2 Rabbit Polyclonal Antibody
蛋白名称
Noelin-2 (Olfactomedin-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93145
Human Swissprot No.
O95897
Human Swissprot Link
https://www.uniprot.org/uniprot/O95897
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=244723
Mouse Swissprot No.
Q8BM13
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BM13/entry
特异性
This antibody detects endogenous levels of OLFM2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in aortic smooth muscle (at protein level) (PubMed:25298399). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup (PubMed:27844144).
细胞定位
Secreted . Cell junction, synapse . Membrane . Nucleus . Cytoplasm . Nuclear localization is induced by TGF-beta. .
功能
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes . Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).
