产品名称
NEK11 Rabbit Polyclonal Antibody
蛋白名称
Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79858
Human Swissprot No.
Q8NG66
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NG66
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208583
Mouse Swissprot No.
Q8C0Q4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C0Q4/entry
特异性
This antibody detects endogenous levels of NEK11 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.
细胞定位
Nucleus . Nucleus, nucleolus . Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910). .
功能
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
