产品名称
ENTPD4 Rabbit Polyclonal Antibody
基因名称
ENTPD4 KIAA0392 LALP70 LYSAL1
蛋白名称
Ectonucleoside triphosphate diphosphohydrolase 4 (NTPDase 4) (EC 3.6.1.6) (Lysosomal apyrase-like protein of 70 kDa) (Uridine-diphosphatase) (UDPase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9583
Human Swissprot No.
Q9Y227
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y227
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100862375
Mouse Swissprot No.
Q9DBT4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DBT4/entry
特异性
This antibody detects endogenous levels of ENTPD4 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highest expression in testis and lowest in bladder.
细胞定位
[Isoform 1]: Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein.; [Isoform 2]: Golgi apparatus membrane ; Multi-pass membrane protein .
功能
[Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates . Preferentially activated by Ca(2+) over Mg(2+) . ; [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally.
