产品名称
PI4K2B Rabbit Polyclonal Antibody
蛋白名称
Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55300
Human Swissprot No.
Q8TCG2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8TCG2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67073
Mouse Swissprot No.
Q8CBQ5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CBQ5/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=305419
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XIL2/entry
特异性
This antibody detects endogenous levels of PI4K2B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm, cytosol . Golgi apparatus membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane . Cell membrane . Early endosome membrane . Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1 (PubMed:12324459). Association with early endosomes has not been confirmed (PubMed:11923287, PubMed:12324459). .
功能
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell . This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments . The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) . Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
