产品名称
Kir2.2 Rabbit Polyclonal Antibody
蛋白名称
ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Inward rectifier K(+) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3768
Human Swissprot No.
Q14500
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14500
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16515
Mouse Swissprot No.
P52187
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P52187/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P52188/entry
特异性
This antibody detects endogenous levels of Kir2.2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
功能
Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
