产品名称
SYT12 Rabbit Polyclonal Antibody
蛋白名称
Synaptotagmin-12 (Synaptotagmin XII) (SytXII)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8IV01
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IV01/entry
Mouse Swissprot No.
Q920N7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q920N7
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97610
免疫原
Synthesized peptide derived from part region of human protein
特异性
SYT12 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
synaptotagmin 12(SYT12) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010],
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass membrane protein .
功能
function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subunit:Homodimer. Can also form heterodimers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
