产品名称
ANKS1B Rabbit Polyclonal Antibody
蛋白名称
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56899
Human Swissprot No.
Q7Z6G8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7Z6G8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77531
Mouse Swissprot No.
Q8BIZ1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BIZ1/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P0C6S7/entry
特异性
This antibody detects endogenous levels of ANKS1B at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
细胞定位
Cytoplasm .; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). .; [Isoform 4]: Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus.
功能
Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. ; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
