产品名称
CCDC65 Rabbit Polyclonal Antibody
蛋白名称
Coiled-coil domain-containing protein 65 (Testis development protein NYD-SP28)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85478
Human Swissprot No.
Q8IXS2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IXS2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=105833
Mouse Swissprot No.
Q8VHI7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VHI7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362994
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XIJ8/entry
特异性
This antibody detects endogenous levels of CCDC65 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in adult testis, in spermatocytes and spermatids. Also observed in spermatogonia. Not detected in Leydig cells, nor in fetal testis (at protein level).
细胞定位
Cytoplasm, cytoskeleton, flagellum basal body . Cell projection, cilium, flagellum . Cytoplasm, cytoskeleton, flagellum axoneme .
功能
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules .
