产品名称
DEF6 Rabbit Polyclonal Antibody
蛋白名称
Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50619
Human Swissprot No.
Q9H4E7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H4E7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23853
Mouse Swissprot No.
Q8C2K1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C2K1/entry
特异性
This antibody detects endogenous levels of DEF6 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Broadly expressed in the immune system and can be detected in T and B-cells.
细胞定位
Cytoplasm . Cell membrane . Nucleus . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell projection, filopodium . Recruited to the plasma membrane upon binding phosphatidylinositol 3,4,5-trisphosphate (PubMed:15023524). Binds to actin filaments (PubMed:15023524). .
功能
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity).
