产品名称
CTMP Rabbit Polyclonal Antibody
蛋白名称
Thioesterase superfamily member 4 (Carboxyl-terminal modulator protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117145
Human Swissprot No.
Q5T1C6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5T1C6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75778
Mouse Swissprot No.
Q3UUI3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UUI3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361992
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q566R0/entry
特异性
This antibody detects endogenous levels of CTMP at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
细胞定位
Cell membrane . Cell projection, ruffle membrane . Cytoplasm . Mitochondrion . Mitochondrion inner membrane; Peripheral membrane protein . Mitochondrion intermembrane space . Released from the mitochondria into the cytosol in response to apoptotic stimuli. .
功能
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
