产品名称
SV2B Rabbit Polyclonal Antibody
蛋白名称
Synaptic vesicle glycoprotein 2B
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7L1I2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7L1I2/entry
Mouse Swissprot No.
Q8BG39
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BG39
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63564
免疫原
Synthesized peptide derived from part region of human protein.AA range 1-50
特异性
SV2B Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016],
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, acrosome . Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). .
信号通路
ECM-receptor interaction;
功能
function:Probably plays a role in the control of regulated secretion in neural and endocrine cells.,PTM:N-glycosylated.,PTM:The N-terminal cytoplasmic domain is phosphorylated by CK1.,similarity:Belongs to the major facilitator superfamily.,subcellular location:Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids.,subunit:Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
