产品名称
TID1 Rabbit Polyclonal Antibody
蛋白名称
DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9093
Human Swissprot No.
Q96EY1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96EY1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83945
Mouse Swissprot No.
Q99M87
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99M87/entry
特异性
This antibody detects endogenous levels of TID1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
细胞定位
Mitochondrion matrix. Cytoplasm, cytosol . Cell junction, synapse, postsynaptic cell membrane ; Peripheral membrane protein . Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. .
功能
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
