产品名称
HMBS Rabbit Polyclonal Antibody
蛋白名称
Porphobilinogen deaminase (PBG-D) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3145
Human Swissprot No.
P08397
Human Swissprot Link
https://www.uniprot.org/uniprot/P08397
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15288
Mouse Swissprot No.
P22907
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P22907/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P19356/entry
特异性
This antibody detects endogenous levels of HMBS at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
[Isoform 1]: Is ubiquitously expressed. ; [Isoform 2]: Is found only in erythroid cells.
功能
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen . Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact .
