产品名称
SV2A Rabbit Polyclonal Antibody
基因名称
SV2A KIAA0736 PSEC0174
蛋白名称
Synaptic vesicle glycoprotein 2A
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q7L0J3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7L0J3/entry
Mouse Swissprot No.
Q9JIS5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JIS5
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q02563
免疫原
Synthesized peptide derived from part region of human protein. AA range 30-80
特异性
SV2A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016],
组织表达
Brain,Brain cortex,Ovary,Retina,Teratocarcinoma,
细胞定位
Cell junction, synapse, presynapse . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. .
信号通路
ECM-receptor interaction;
功能
function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.,miscellaneous:Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.,PTM:N-glycosylated.,PTM:Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.,similarity:Belongs to the major facilitator superfamily.,subcellular location:Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.,subunit:Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
