产品名称
KATNAL1 Rabbit Polyclonal Antibody
蛋白名称
Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 3.6.4.3) (p60 katanin-like 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84056
Human Swissprot No.
Q9BW62
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BW62
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231912
Mouse Swissprot No.
Q8K0T4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0T4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100910196
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XIK7/entry
特异性
This antibody detects endogenous levels of KATNAL1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in testis, restricted to Sertoli cells (at protein level).
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, spindle . Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). .
功能
Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro .
