产品名称
SYN3 Rabbit Polyclonal Antibody
蛋白名称
Synapsin-3 (Synapsin III)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O14994
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14994/entry
Mouse Swissprot No.
Q8JZP2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8JZP2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941O70441
免疫原
Synthesized peptide derived from part region of human protein. AA range 530-580
特异性
SYN3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite directi
组织表达
Neuron specific. Detected predominantly in brain.
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
功能
function:May be involved in the regulation of neurotransmitter release and synaptogenesis.,miscellaneous:Regulated by calcium. Calcium inhibits ATP binding to the C-domain.,similarity:Belongs to the synapsin family.,subcellular location:Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.,subunit:Interacts with CAPON.,tissue specificity:Neuron specific. Detected predominantly in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
